Some quick facts

Edition
11th
Institutes to be visited
18
Number of sponsors to support us
14

Research of the Laboratory of Organic Chemistry

The research conducted within the Laboratory of Organic Chemistry is directed towards the study of organic reactivity at the forefront of 21st century chemistry, specifically at the overlap of nanotechnology, chemical biology, and organic synthesis. In micro- and nanotechnology the goal is to come to really tiny devices, with the aims of e.g. increased speed and sensitivity of analysis.  In such miniature devices the area becomes relatively very large (increased area/volume ratio), and as such ‘cries out’ for increased control over surface properties. In our lab we are closely observing surfaces, and develop or fine-tune their chemistry to allow functionalization with (bio-)organic materials. These can either be covalently attached, or deposited as a thin layer on top of the surface. This has e.g. led to novel functionalizations of glass, Si, SiC and Cu surfaces with a range of bio-functional moieties.

In this area we are both interested in the fundamental aspects as well as in the application thereof in practically relevant devices. Examples thereof include protein-repelling microsieves, non-oxidizing silicon, switchable liquid crystals, tailor-made microchannels with oligosaccharides that selectively capture toxic antibodies, and micropatterned, biofunctional Cu for biosensing purposes, leading to both highly cited scientific papers as well as 5 patents since 2005. Apart from using these reactions, we also try to develop novel routes, partially to allow milder surface chemistry, but also to open new entries to long-known compounds. Our aim here is to use the toolbox of bio-organic chemistry to further develop the area of bio-based synthesis, so as to allow the use of agrochemicals and (preferably) currently unused agrochemical wastestreams as building blocks for bulk synthesis.

Accompanying scientific staff

prof. dr. J. T. (Han) Zuilhof Han Zuilhof is the Chair of Organic Chemistry at Wageningen University. His interests focus on surface-bound (bio-)organic chemistry and bio-nanotechnology. He is the author of > 300 peer-reviewed papers, including 5 reviews, and has written 11 patents, of which 9 were sold to companies. He is also a Distinguished Adjunct Professor of Chemical Engineering at the King Abdulaziz University in Jeddah, Saudi Arabia, a Distinguished Perennial Guest Professor of Medicinal Chemistry, Tianjin University, Tianjin, China, is the founder of a spin-off company Surfix, is senior editor of Langmuir, and was the 2013-2014 Joseph Meyerhoff Visiting Professor of Chemistry at the Weizmann Institute of Science. As organic chemist at Wageningen University he is predominantly looking for novel concepts to link biological activity of interest via the tricks of the trade of organic chemistry to surfaces. This interdisciplinary science is really cool. Many processes of interest (conversions, molecular capture, catalysis) occur at a surface, yet relatively little organic chemistry is focussed on surfaces. This provides significant chances and challenges for organic chemistry and organic materials. Our lab is extremely well equipped for such studies, and the setting of Wageningen University - a world-class university focussed on life sciences - allows for an excellent embedding thereof!
dr.ing. H.B. (Bauke) Albada Bauke Albada is assistant professor in the Laboratory of Organic Chemistry. His research explores the boundaries between Chemistry and Biology. Inspired by nature, his group develops novel approaches to: (i) site-selectively modify proteins, (ii) identify the molecular mechanism by which omega-3 fatty acids interact with human inflammation pathways, (iii) functionalizes a wide variety of surfaces with biosensors or biomimetic catalysts, and (iv) explores novel methods to combat bacterial infections. We collaborate with various groups within the Wageningen University & Research community, other groups in The Netherlands, and abroad. My work has been published in leading chemistry journals like PNAS, JACS, and Angew Chem, and he published reviews in Chem Rev and Acc Chem Res. During his stay in the laboratory of prof. dr. Itamar Willner in Jerusalem (The Hebrew University of Jerusalem, Israel), he developed DNA architectures as novel catalytic entities and sensing modules.

The PhD Students from the Laboratory of Organic Chemistry

Please allow us to introduce ourselves below. You can click on our pictures for more information. There will be more colleagues joining our group later; they will be added once their participation in the trip is confirmed.

Esther Roeven

New macromolecular building blocks for ambient zwitterionic antifouling coatings

Annemieke van Dam

Self-Repairing Antifouling Fluorinated Polymer Brushes: multiple fluorinated polymer brushes are tested on their ability to repel organic fouling materials. Also their self-repairing behaviour is investigated, both experimentally and with simulations.

Andryi Kuzmyn

To create new approaches for design and development of bioactive non-fouling surfaces for further utilization in flow-through microsieve-based biosensors.

Jorick Bruins

Site-specific conjugation of biological agents to antibodies

Jordi Keijzer

Switchable enzyme reactions

Ian de Bus

Fishing for endogenous inhibitors of inflammation derived from omega-3 fatty acids; unravelling the interactions between N-docosahexaenoylethanolamide and cyclooxygenase-2.

Kaustub Singh

This research project will focus on the search of advanced material to prepare electrodes to be used in Capacitive Deionization. This electrochemical technology will be useful in recovery of ions from waste water and their storage into the electrodes.

Pepijn Beekman

Capturing of Extracellular Vesicles on modified surfaces for cancer diagnosis using various characterization tools, e.g. electrochemistry, Raman Spectroscopy, scanning electron microscopy and atomic force microscopy

Milou Santbergen

To study in vitro pharmacokinetics more realistically, by on-line coupling of mass spectrometry analysis to a gut-on-a-chip. Resulting in a better prediction of the in vivo situation.

Gina Ross

Developing affordable multiplex smartphone based immunoassays for food allergens

Sevil Sahin

Design, synthesis and characterization of ultra-thin, nanometer-sized and ion-selective polymeric membranes which will be used in electro-driven separation processes.

Alice Guarneri

Nicotinamide coenzyme biomimetics in biocatalysis

Michel de Haan

Beauti-Fully BioBased Fibers; Improving natural colorants to be used in man-made fibers.

Our Itinerary

We are currently contacting institutes and composing a programme. When new destinations are confirmed, they will be added to the itinerary.